Temporal changes of hepatic drug-metabolizing enzymes mediated by hepatic ischemia-reperfusion injury and the protective effect of Oridonin

Temporal changes of hepatic drug-metabolizing enzymes mediated by hepatic ischemia-reperfusion injury and the protective effect of Oridonin

Abstract Hepatic ischemia-reperfusion injury (IRI) is a common complication associated with metabolic disturbances and postoperative liver failure. Despite its prevalence, there is still a significant gap in understanding the changes in hepatic drug-metabolizing enzymes—specifically cytochrome P450s...

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Main Authors: Tanwei Gu, Fahong Dai, Meiqun Cai, Xi Zhang, Danni Xie, Huanguo Jiang, Lingmin Tian, Liyan Yan, Wenxun Lan, Haitao Lv, Lan Tang, Hong Li, Zhaoguo Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Oridonin
Hepatic ischemia-reperfusion injury
CYPs/UGTs
Temporal changes
Oxidative stress
Online Access:https://doi.org/10.1038/s41598-025-06179-3
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https://doi.org/10.1038/s41598-025-06179-3

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