Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice

Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice

IntroductionSevere injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response effectively. Additionally, a clear biomarker profile to guide...

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Bibliographic Details
Main Authors: Micah L. Willis, Roland F. Seim, Laura E. Herring, Angie L. Mordant, Thomas S. Webb, Gilbert R. Upchurch, Ashish K. Sharma, Bruce A. Cairns, Philip A. Efron, Shannon M. Wallet, Leon G. Coleman, Robert Maile
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
burn injury
extracellular vesicles
thermal injury
macrophages
microvesicles
exosomes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1596598/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1596598/full

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