Targeting Dicer reprograms tumor-associated macrophages to promote anti-tumoral immunity in colorectal cancer liver metastasis

Targeting Dicer reprograms tumor-associated macrophages to promote anti-tumoral immunity in colorectal cancer liver metastasis

Abstract Background Tumor-associated macrophages (TAMs) contribute significantly to immunosuppression in colorectal cancer liver metastasis (CRLM), leading to high aggressiveness and poor prognosis. However, the key molecules involved in shaping TAMs toward the pro-tumoral phenotype in CRLM remain u...

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Bibliographic Details
Main Authors: Shenglong Xia, Wenwen Chen, Zhengyang Xu, Yuzhen Gao, Jingyu Chen, Ning Ding, Ying Zhang, Tianhua Zhou, Xuefei Zhou, Xiangrui Liu, Meng Xue
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Colorectal cancer
Liver metastasis
Tumor-associated macrophages
Dicer
RNA-lipid nanoparticles
Online Access:https://doi.org/10.1186/s12951-025-03518-4
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https://doi.org/10.1186/s12951-025-03518-4

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