Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy
Myeloproliferative disorders are variable disorders, based on the genetic abnormality present and the cell line progenitors that are affected. In this case, we discuss a novel gene translocation in the subset of PDGFRB mutations, first seen with prominent hyperbasophilia. This case demonstrates the...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/709164 |
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| _version_ | 1832545883144585216 |
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| author | Joel D. Provenzano J. Phillip Kuebler |
| author_facet | Joel D. Provenzano J. Phillip Kuebler |
| author_sort | Joel D. Provenzano |
| collection | DOAJ |
| description | Myeloproliferative disorders are variable disorders, based on the genetic abnormality present and the cell line progenitors that are affected. In this case, we discuss a novel gene translocation in the subset of PDGFRB mutations, first seen with prominent hyperbasophilia. This case demonstrates the possibility for lower therapeutic doses of imatinib mesylate than previously reported, in order to control leukocyte counts and reverse the genetic mutation. |
| format | Article |
| id | doaj-art-d7cb57aa654c444684fd20c8dcfad3b6 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d7cb57aa654c444684fd20c8dcfad3b62025-02-03T07:24:30ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/709164709164Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment StrategyJoel D. Provenzano0J. Phillip Kuebler1Riverside Methodist Hospital, Columbus, OH, USARiverside Methodist Hospital, Columbus, OH, USAMyeloproliferative disorders are variable disorders, based on the genetic abnormality present and the cell line progenitors that are affected. In this case, we discuss a novel gene translocation in the subset of PDGFRB mutations, first seen with prominent hyperbasophilia. This case demonstrates the possibility for lower therapeutic doses of imatinib mesylate than previously reported, in order to control leukocyte counts and reverse the genetic mutation.http://dx.doi.org/10.1155/2013/709164 |
| spellingShingle | Joel D. Provenzano J. Phillip Kuebler Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy Case Reports in Hematology |
| title | Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy |
| title_full | Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy |
| title_fullStr | Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy |
| title_full_unstemmed | Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy |
| title_short | Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy |
| title_sort | novel t 5 19 translocation in a patient with pdgfrb associated chronic leukemia implications for treatment strategy |
| url | http://dx.doi.org/10.1155/2013/709164 |
| work_keys_str_mv | AT joeldprovenzano novelt519translocationinapatientwithpdgfrbassociatedchronicleukemiaimplicationsfortreatmentstrategy AT jphillipkuebler novelt519translocationinapatientwithpdgfrbassociatedchronicleukemiaimplicationsfortreatmentstrategy |