Assessing the MUC5B promoter variant in a large cohort of systemic sclerosis-associated interstitial lung disease

Assessing the MUC5B promoter variant in a large cohort of systemic sclerosis-associated interstitial lung disease

Objective The common gain-of-function variant rs35705950, located in the promoter of MUC5B gene, has been strongly associated with interstitial lung diseases (ILDs) of different aetiology, such as idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis-associated ILD (RA-ILD). In this study, we...

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Main Authors: Yannick Allanore, Marialbert Acosta-Herrera, Martin Kerick, Oliver Distler, Christopher P Denton, Alexandre E Voskuyl, Mandana Nikpour, Lorenzo Beretta, Javier Martin, Maureen D Mayes, Shervin Assassi, Ariane L Herrick, Alexander Kreuter, Nicolas Hunzelmann, P Airò, A Barton, G Riemekasten, Susanna M Proudman, F J López-Longo, E Beltrán, C Fonseca, B Fernandez-Gutierrez, A Nordin, M Freire, L Rodriguez-Rodriguez, G Major, Jeska K de Vries-Bouwstra, M A Gonzalez-Gay, G ESPINOSA, T R D J Radstake, A Gabrielli, F Diaz, V Ortiz-Santamaria, L Padyukov, G Orozco, T Witte, J Walker, W Stevens, C Lunardi, N Oreiro, José Luis Callejas, P Carreira, I Castellvi, R Ríos, R García Portales, A Fernández-Nebro, F J García-Hernández, M A Aguirre, P García de la Peña, E Vicente, J L Andreu, M Fernández de Castro, V Fonollosa, A Pros, M Rodríguez Carballeira, F J Narváez, M Rubio Rivas, A B Madroñero, B Díaz, L Trapiella, M V Egurbide, P Fanlo-Mateo, L Saez-Comet, J A Roman-Ivorra, J J Alegre Sancho, F J Blanco Garcia, C Magro, M C Vonk, R Hesselstrand, A Hoffmann-Vold, J H W Distler, J Sahhar, N Ortego-Centeno, B P C Koeleman, D Hansen, A Apostolopoulos, L Ross, G Moroncini, Alfredo Guillén-Del-Castillo, Carmen P Simeon-Aznar, Carlos Rosa-Baez, Carlos Rangel-Pelaez, Inmaculada Rodriguez-Martin, L Tío, N Ferdowsi, L V Host, G S Ngian, A Quinlivan, M Tabesh
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/11/3/e005754.full
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