Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens

Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens

Abstract Background The rapid mutation of avian influenza virus (AIV) poses a significant threat to both the poultry industry and public health. Herein, we have successfully developed an mRNA-LNPs candidate vaccine for H5 subtype highly pathogenic avian influenza and evaluated its immunogenicity and...

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Main Authors: Zhaoyang Wang, Chongyu Tian, Jiahang Zhu, Shiqian Wang, Xiang Ao, Yanjuan He, Huixin Chen, Xiuying Liao, Deming Kong, Yongfei Zhou, Wanbo Tai, Ming Liao, Huiying Fan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Nanobiotechnology
Subjects:
H5N1
HA
mRNA vaccine
Lipid nanoparticle
mRNA secondary structure
Online Access:https://doi.org/10.1186/s12951-025-03156-w
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https://doi.org/10.1186/s12951-025-03156-w

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