Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.

Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.

Francisella tularensis infects macrophages and escapes phago-lysosomal fusion to replicate within the host cytosol, resulting in host cell apoptosis. Here we show that the Fas-mediated death pathway is activated in infected cells and correlates with escape of the bacterium from the phagosome and the...

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Main Authors: Murugesan V S Rajaram, Jonathan P Butchar, Kishore V L Parsa, Thomas J Cremer, Amal Amer, Larry S Schlesinger, Susheela Tridandapani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007919&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007919&type=printable

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