Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases

Abstract Rodents are the most commonly used laboratory animals in medical research. However, significant evolutionary divergences between humans and rodents, particularly in the complexity of white matter connectome, which are fundamentally shaped by myelin as their major structural component, pose...

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Bibliographic Details
Main Authors: Wenxuan Zhou, Shiyue Xia, Chenmeng Wang, Qingwu Yang, Alexei Verkhratsky, Jianqin Niu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07893-6
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