Cardioprotection by poloxamer 188 is mediated through increased endothelial nitric oxide production

Cardioprotection by poloxamer 188 is mediated through increased endothelial nitric oxide production

Abstract Ischemia/reperfusion (I/R) injury significantly contributes to the morbidity and mortality associated with cardiac events. Poloxamer 188 (P188), a non-ionic triblock copolymer, has been proposed to mitigate I/R injury by stabilizing cell membranes. However, the underlying mechanisms remain...

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Bibliographic Details
Main Authors: Gaoxian Chen, Hunter F. Douglas, Zhu Li, William J. Cleveland, Claudius Balzer, Demetris Yannopoulos, Ian Y. Chen, Detlef Obal, Matthias L. Riess
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Cardiac arrest
Copolymer
Ischemia/reperfusion injury
Myocardial infarction
NO
P188
Online Access:https://doi.org/10.1038/s41598-025-97079-z
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https://doi.org/10.1038/s41598-025-97079-z

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