Effects of proximal tubule-specific ATRAP enhancement on hypertension in a remnant kidney chronic kidney disease model of mice

Effects of proximal tubule-specific ATRAP enhancement on hypertension in a remnant kidney chronic kidney disease model of mice

Abstract Chronic kidney disease (CKD) frequently accompanies hypertension, exacerbating CKD progression in a vicious cycle. Angiotensin II type 1 receptor-associated protein (ATRAP) promotes AT1 receptor internalization to inhibit hyperactivation of its downstream signaling. We previously reported t...

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Main Authors: Naohito Okami, Hiromichi Wakui, Shohei Tanaka, Ryu Kobayashi, Shunichiro Tsukamoto, Shinya Taguchi, Ryutaro Morita, Eisuke Kubo, Akio Yamashita, Kengo Azushima, Kouichi Tamura
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
5/6 nephrectomy
Chronic kidney disease
Renal tubules
Angiotensins
Hypertension
Online Access:https://doi.org/10.1038/s41598-025-12168-3
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https://doi.org/10.1038/s41598-025-12168-3

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