Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing

Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing

IntroductionThe prognostic management of acute myeloid leukemia (AML) remains a challenge for clinicians. This study aims to construct a novel risk model for AML patient through comprehensive analysis of scRNA and bulk RNA data to optimize the precise treatment strategies for patients and improve pr...

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Main Authors: Yongfen Huang, Ping Yi, Yixuan Wang, Lingling Wang, Yongqin Cao, Jingbo Lu, Kun Fang, Yuexin Cheng, Yuqing Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
acute myeloid leukemia
ScRNA-seq
bulk RNA-seq
prognostic signature
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565954/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565954/full

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