Enhanced THBS2 promotes collagen synthesis and inflammatory secretome of fibroblasts in idiopathic pulmonary fibrosis

Enhanced THBS2 promotes collagen synthesis and inflammatory secretome of fibroblasts in idiopathic pulmonary fibrosis

Abstract The pathogenesis of pulmonary fibrosis involves structural remodeling and functional impairment of lung tissue, accompanied by increased secretion of pro-inflammatory mediators and abnormal synthesis of the extracellular matrix (ECM). Thrombospondin-2 (THBS2), an ECM glycoprotein encoding g...

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Bibliographic Details
Main Authors: Lu Yu, Rui Wang, Qinhui Hou, Fan Yang, Ying Liu, Meiting Peng, Yihan Dong, Yuan Liu, Zhenshun Cheng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
THBS2
Extracellular matrix
Inflammation secretome
Idiopathic pulmonary fibrosis
Online Access:https://doi.org/10.1038/s41598-025-09318-y
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https://doi.org/10.1038/s41598-025-09318-y

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