HIPSD&R-seq enables scalable genomic copy number and transcriptome profiling

HIPSD&R-seq enables scalable genomic copy number and transcriptome profiling

Abstract Single-cell DNA sequencing (scDNA-seq) enables decoding somatic cancer variation. Existing methods are hampered by low throughput or cannot be combined with transcriptome sequencing in the same cell. We propose HIPSD&R-seq (HIgh-throughPut Single-cell Dna and Rna-seq), a scalable yet si...

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Main Authors: Jan Otoničar, Olga Lazareva, Jan-Philipp Mallm, Milena Simovic-Lorenz, George Philippos, Pooja Sant, Urja Parekh, Linda Hammann, Albert Li, Umut Yildiz, Mikael Marttinen, Judith Zaugg, Kyung Min Noh, Oliver Stegle, Aurélie Ernst
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Biology
Subjects:
Single Cell DNA sequencing
Single Cell multiome
Single Cell copy Number profiling
Online Access:https://doi.org/10.1186/s13059-024-03450-0
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https://doi.org/10.1186/s13059-024-03450-0

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