Rational development of an attenuated recombinant cyprinid herpesvirus 3 vaccine using prokaryotic mutagenesis and in vivo bioluminescent imaging.

Rational development of an attenuated recombinant cyprinid herpesvirus 3 vaccine using prokaryotic mutagenesis and in vivo bioluminescent imaging.

Cyprinid herpesvirus 3 (CyHV 3) is causing severe economic losses worldwide in common and koi carp industries, and a safe and efficacious attenuated vaccine compatible with mass vaccination is needed. We produced single deleted recombinants using prokaryotic mutagenesis. When producing a recombinant...

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Main Authors: Maxime Boutier, Maygane Ronsmans, Ping Ouyang, Guillaume Fournier, Anca Reschner, Krzysztof Rakus, Gavin S Wilkie, Frédéric Farnir, Calixte Bayrou, François Lieffrig, Hong Li, Daniel Desmecht, Andrew J Davison, Alain Vanderplasschen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004690
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https://doi.org/10.1371/journal.ppat.1004690

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