Oxidation-induced destabilization of polymorphic α-synuclein fibrils: insights from molecular dynamics
The build-up of α-Synuclein (αSyn) fibrils is a key feature of Parkinson’s disease (PD) and other synucleinopathies. While oxidative stress has been implicated in αSyn aggregation, its precise effects on fibril stability remain unclear. In this study, we use molecular dynamics (MD) simulations and e...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Physics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphy.2025.1591640/full |
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