Interaction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol: Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects

Despite a long history in medical and dental application, the molecular mechanism and precise site of action are still arguable for local anesthetics. Their effects are considered to be induced by acting on functional proteins, on membrane lipids, or on both. Local anesthetics primarily interact wit...

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Bibliographic Details
Main Authors: Hironori Tsuchiya, Maki Mizogami
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Anesthesiology Research and Practice
Online Access:http://dx.doi.org/10.1155/2013/297141
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