Study of acute lethality, teratogenesis, and metabolomic changes of N-(2’-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) on Artemia franciscana

Study of acute lethality, teratogenesis, and metabolomic changes of N-(2’-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) on Artemia franciscana

Abstract The brine shrimp lethality test (Artemia spp.) is a classical model for assessing the toxicity of bioactive compounds. This study evaluated the toxicity and metabolomic changes induced by N-(2’- hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), a derivative of valproic acid (VPA), in Artemia f...

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Main Authors: Cynthia Fernández-Pomares, Alan Rubén Estrada-Pérez, Humberto L. Mendoza-Figueroa, Juan Benjamín García-Vázquez, Martha C. Rosales-Hernández, José Correa-Basurto
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Acute toxicity text
LC-MS/MS
Valproic acid
Histone deacetylase inhibitors
Untargeted metabolomics.
Online Access:https://doi.org/10.1038/s41598-025-03325-9
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https://doi.org/10.1038/s41598-025-03325-9

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