Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway

Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway

Hyperlipidemia and chronic kidney disease (CKD) are well-established risk factors for cardiovascular disease and act synergistically to promote vascular inflammation and disease progression. However, the mechanisms underlying this synergetic effect remain largely unknown. Using a mouse model combini...

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Bibliographic Details
Main Authors: Yifan Lu, Yu Sun, Fatma Saaoud, Keman Xu, Ying Shao, Baosheng Han, Xiaohua Jiang, Laisel Martinez, Roberto I. Vazquez-Padron, Sadia Mohsin, Huaqing Zhao, Hong Wang, Xiaofeng Yang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Uremic toxin receptors
NR1H3-YBX2 axis
Chronic kidney disease (CKD)
Hyperlipidemia
Vascular inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172500237X
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