Machine learning-assisted rational design and evolution of novel signal peptides in Yarrowia lipolytica

Microbial proteins hold great promise as sustainable alternatives for future protein sources, and oleaginous yeast Yarrowia lipolytica has emerged as a recognized platform for heterologous protein expression and secretion. N-terminal signal peptides (SPs) are crucial for directing proteins to the se...

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Bibliographic Details
Main Authors: Zizhao Wu, Wenhao Chen, Yuxiang Hong, Yongkai Wang, Peng Xu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Synthetic and Systems Biotechnology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X2500105X
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