Multi‐omics profiling identifies TNFRSF18 as a novel marker of exhausted CD8⁺ T cells and reveals tumour‐immune dynamics in colorectal cancer

Multi‐omics profiling identifies TNFRSF18 as a novel marker of exhausted CD8⁺ T cells and reveals tumour‐immune dynamics in colorectal cancer

Abstract Background Colorectal cancer (CRC) ranks among the most prevalent malignant tumours of the digestive system globally and is associated with unfavourable survival outcomes. The exhaustion of CD8⁺ T cells serves a crucial role in facilitating tumour immune escape. Yet, the dynamic evolution o...

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Bibliographic Details
Main Authors: Tengfei Jia, Yingxi Guo, Xin meng Cheng, Zeyang Zhou, Xiaojiang Xu, Hebin Liu, Xiaodong Yang
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Clinical and Translational Medicine
Subjects:
colorectal cancer
singlecell RNA sequencing
spatial transcriptomics
T cell exhaustion
TNFRSF18 (GITR)
TNM stage
Online Access:https://doi.org/10.1002/ctm2.70425
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https://doi.org/10.1002/ctm2.70425

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