Predicting survival in prospective clinical trials using weakly-supervised QSP

Abstract Quantitative systems pharmacology (QSP) models of cancer immunity provide mechanistic insights into cellular dynamics and drug effects that are difficult to study clinically. However, their inability to predict patient survival mechanistically limits their utility in anti-cancer drug develo...

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Bibliographic Details
Main Authors: Matthew West, Kenta Yoshida, Jiajie Yu, Vincent Lemaire
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00898-6
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