NcROP2 deletion reduces Neospora caninum virulence by altering parasite stage differentiation and hijacking host immune response

NcROP2 deletion reduces Neospora caninum virulence by altering parasite stage differentiation and hijacking host immune response

IntroductionNeospora caninum is an apicomplexan parasite responsible for bovine neosporosis, a major cause of abortion in cattle worldwide. N. caninum rhoptry protein 2 (NcROP2) has been identified as an essential factor in host cell invasion and parasitophorous vacuole formation, making it a potent...

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Bibliographic Details
Main Authors: Rafael Amieva, Montserrat Coronado, Jessica Powell, David Arranz-Solís, Musa A. Hassan, Esther Collantes-Fernández, Luis Miguel Ortega-Mora, Pilar Horcajo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
Neospora caninum
virulence factor
NcROP2
CRISPR/Cas9
BALB/c
bovine macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617570/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1617570/full

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