Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival

Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival

Abstract Background Hypomagnesemia has been correlated with inferior outcomes in patients with large B cell lymphoma (LBCL) undergoing stem cell transplants. As T-cell and myeloid cell dysfunction have been associated with low magnesium conditions, we investigated whether serum magnesium (Mg) levels...

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Main Authors: Jennifer J. Gile, Patrizia Mondello, Zixing Wang, Ying Li, Radhika Bansal, Sangeetha Gandhi, Henan Zhang, Elham Babadi, Kodi Martinez, Gabrielle McCoy, Zuoyi Shao, Kevin Regan, Matthew A. Hathcock, Panwen Wang, Junwen Wang, Abdullah S. Al Saleh, Gordon Ruan, Stephen M. Ansell, N. Nora Bennani, Patrick B. Johnston, Jonas Paludo, Jose C. Villasboas-Bisneto, Arushi Khurana, Urshila Durani, Yucai Wang, Paul J. Hampel, Allison Rosenthal, Javier Munoz, Eider Moreno, Januario E. Castro, Hemant S. Murthy, Mohamed Kharfan-Dabaja, Saad S. Kenderian, Jenny J. Kim, Rhine Shen, Mike Mattie, Yi Lin, Thomas E. Witzig
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Experimental Hematology & Oncology
Subjects:
Lymphoma
Magnesium
Cytokines
Survival analysis
CAR-T
Online Access:https://doi.org/10.1186/s40164-025-00623-w
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https://doi.org/10.1186/s40164-025-00623-w

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