Histone lactylation as a driver of metabolic reprogramming and immune evasion
Lactate is the end product of glycolysis, and extensive research has shown that lactate participates in various pathophysiological processes. Along with associated hydrogen ions, lactate typically functions as an immunosuppressive negative factor and plays a crucial role in tumor metabolic reprogram...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Medical Review |
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| Online Access: | https://doi.org/10.1515/mr-2024-0091 |
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| author | Cai Qiaoting Deng Wei Zou Yutian Chen Zhe-Sheng Tang Hailin |
| author_facet | Cai Qiaoting Deng Wei Zou Yutian Chen Zhe-Sheng Tang Hailin |
| author_sort | Cai Qiaoting |
| collection | DOAJ |
| description | Lactate is the end product of glycolysis, and extensive research has shown that lactate participates in various pathophysiological processes. Along with associated hydrogen ions, lactate typically functions as an immunosuppressive negative factor and plays a crucial role in tumor metabolic reprogramming. The recently discovered lactylation is a novel epigenetic modification that, similar to other epigenetic modifications, modifies histones to alter chromatin spatial configuration, thereby affecting DNA accessibility and regulating gene expression. More importantly, the degree of lactylation is closely related to local lactate concentrations, establishing a link between epigenetics and metabolic reprogramming. During cellular metabolism, lactate accumulation promotes histone lysine lactylation in cancer cells and immune cells such as macrophages and T cells, playing an essential role in tumor immune evasion and resistance to immunotherapy. This paper details the role of lactylation modifications in cancer immune evasion and resistance to immunotherapy, providing novel therapeutic directions and targets for cancer treatment. |
| format | Article |
| id | doaj-art-d6aea56ea07c40d0b1a9ebbd86894f77 |
| institution | Kabale University |
| issn | 2749-9642 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Medical Review |
| spelling | doaj-art-d6aea56ea07c40d0b1a9ebbd86894f772025-08-20T03:28:32ZengDe GruyterMedical Review2749-96422024-12-015325625910.1515/mr-2024-0091Histone lactylation as a driver of metabolic reprogramming and immune evasionCai Qiaoting0Deng Wei1Zou Yutian2Chen Zhe-Sheng3Tang Hailin4State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaCollege of Pharmacy and Health Sciences, St. John’s University, Queens, NY, USAState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, ChinaLactate is the end product of glycolysis, and extensive research has shown that lactate participates in various pathophysiological processes. Along with associated hydrogen ions, lactate typically functions as an immunosuppressive negative factor and plays a crucial role in tumor metabolic reprogramming. The recently discovered lactylation is a novel epigenetic modification that, similar to other epigenetic modifications, modifies histones to alter chromatin spatial configuration, thereby affecting DNA accessibility and regulating gene expression. More importantly, the degree of lactylation is closely related to local lactate concentrations, establishing a link between epigenetics and metabolic reprogramming. During cellular metabolism, lactate accumulation promotes histone lysine lactylation in cancer cells and immune cells such as macrophages and T cells, playing an essential role in tumor immune evasion and resistance to immunotherapy. This paper details the role of lactylation modifications in cancer immune evasion and resistance to immunotherapy, providing novel therapeutic directions and targets for cancer treatment.https://doi.org/10.1515/mr-2024-0091cancerimmune escapehistone lactylationimmunotherapy resistance |
| spellingShingle | Cai Qiaoting Deng Wei Zou Yutian Chen Zhe-Sheng Tang Hailin Histone lactylation as a driver of metabolic reprogramming and immune evasion Medical Review cancer immune escape histone lactylation immunotherapy resistance |
| title | Histone lactylation as a driver of metabolic reprogramming and immune evasion |
| title_full | Histone lactylation as a driver of metabolic reprogramming and immune evasion |
| title_fullStr | Histone lactylation as a driver of metabolic reprogramming and immune evasion |
| title_full_unstemmed | Histone lactylation as a driver of metabolic reprogramming and immune evasion |
| title_short | Histone lactylation as a driver of metabolic reprogramming and immune evasion |
| title_sort | histone lactylation as a driver of metabolic reprogramming and immune evasion |
| topic | cancer immune escape histone lactylation immunotherapy resistance |
| url | https://doi.org/10.1515/mr-2024-0091 |
| work_keys_str_mv | AT caiqiaoting histonelactylationasadriverofmetabolicreprogrammingandimmuneevasion AT dengwei histonelactylationasadriverofmetabolicreprogrammingandimmuneevasion AT zouyutian histonelactylationasadriverofmetabolicreprogrammingandimmuneevasion AT chenzhesheng histonelactylationasadriverofmetabolicreprogrammingandimmuneevasion AT tanghailin histonelactylationasadriverofmetabolicreprogrammingandimmuneevasion |