Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways

Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways

Abstract Background Engineered cells provide versatile tools for precise, tunable drug delivery, especially when synthetic stimulus-responsive gene circuits are incorporated. In many complex disease conditions, endogenous pathologic signals such as inflammation can vary dynamically over different ti...

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Bibliographic Details
Main Authors: Amanda Cimino, Fiona Pat, Omolabake Oyebamiji, Christine T.N. Pham, Erik D. Herzog, Farshid Guilak
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Biological Engineering
Subjects:
Synthetic biology
Cell engineering
Gene circuits
Cartilage
Arthritis
Circadian rhythms
Online Access:https://doi.org/10.1186/s13036-025-00519-7
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https://doi.org/10.1186/s13036-025-00519-7

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