Japanese nationwide dental survey of hypophosphatasia reveals novel oral manifestations

Japanese nationwide dental survey of hypophosphatasia reveals novel oral manifestations

Abstract Hypophosphatasia (HPP) is a common inherited skeletal disease. Early exfoliation of primary teeth is known as a dental manifestation of HPP, and sometimes this symptom leads to a diagnosis of HPP. This study aimed to investigate the dental manifestations of HPP in the Japanese population, f...

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Bibliographic Details
Main Authors: Rena Okawa, Tamami Kadota, Hiroshi Kurosaka, Hirofumi Nakayama, Marin Ochiai, Yuko Ogaya, Takuo Kubota, Takashi Yamashiro, Kazuhiko Nakano
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Alkaline phosphatase
Dysphagia
Early exfoliation
Enamel hypoplasia
Hypophosphatasia
Malocclusion
Online Access:https://doi.org/10.1038/s41598-025-91043-7
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https://doi.org/10.1038/s41598-025-91043-7

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