Quantitative detection of pseudouridine in RNA by mass spectrometry

Abstract Pseudouridine (Ψ) is one of the most prevalent and dynamic modification in RNA, and was shown to evade the host immune response in mRNA vaccines. Despite its significance, the biological role of Ψ remains poorly understood as certain key limitations and challenges in the detection of Ψ are...

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Bibliographic Details
Main Authors: Shanice Jessica Hermon, Anastasia Sennikova, Sidney Becker
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-78734-3
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