Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics.

Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics.

Drugs targeting the ER-resident innate immune receptor Stimulator of Interferon Genes (STING) are in development for treatments of cancer and inflammatory diseases. Accurate determination of STING receptor levels in normal and disease tissue is an essential component of modeling pharmacology and dru...

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Main Authors: Thomas E Angel, Zhuo Chen, Ahmed Moghieb, Sze-Ling Ng, Allison M Beal, Carol Capriotti, Leonard Azzarano, Debra Comroe, Michael Adam, Patrick Moore, Bao Hoang, Kelly Blough, Joanne Kuziw, Joshi M Ramanjulu, G Scott Pesiridis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0319216
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https://doi.org/10.1371/journal.pone.0319216

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