Structure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue

Structure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue

Majusculamide D, isolated from the marine cyanobacterium <i>Moorea producens</i>, is an anticancer lipopentapeptide consisting of fatty acid, tripeptide, and pyrrolyl proline moieties. In this work, by utilizing a convergent synthetic approach, late-stage modification, and bioisostere st...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiuhe Zhao, Xiaonan Xi, Mingxiao Zhang, Mengxue Lv, Xiang Zhang, Yaxin Lu, Liang Wang, Yue Chen
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Marine Drugs
Subjects:
structure-activity relationship
natural products
anticancer
pancreatic cancer
metastasis
Online Access:https://www.mdpi.com/1660-3397/22/12/537
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1660-3397/22/12/537

Similar Items