The role of peripheral innate immune cells in Alzheimer’s disease progression

The role of peripheral innate immune cells in Alzheimer’s disease progression

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, and chronic neuroinflammation. While microglia and astrocytes dominate CNS immune responses, emerging evidence implicates peripheral innate immune cells (PIICs)—including neutro...

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Bibliographic Details
Main Authors: Yanchun Cao, Ke Tang, Pengcheng Ma, Run Zhang, Yani Yang, Tingting Li, Ying Zhang, Xiaoming Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Alzheimer’s disease
peripheral innate immunity
neuroinflammation
trained immunity
genetic polymorphisms
myeloid-derived suppressor cells (MDSCs)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616939/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616939/full

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