Integrative single-cell and exosomal multi-omics uncovers SCNN1A and EFNA1 as non-invasive biomarkers and drivers of ovarian cancer metastasis

Integrative single-cell and exosomal multi-omics uncovers SCNN1A and EFNA1 as non-invasive biomarkers and drivers of ovarian cancer metastasis

BackgroundOvarian cancer (OV) is the deadliest gynecologic malignancy owing to its late diagnosis and high metastatic propensity. Current biomarkers lack sufficient sensitivity and specificity for the detection of early-stage cancer. To address this gap, we integrated single‐cell transcriptomic prof...

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Bibliographic Details
Main Authors: Liping Tang, Dong Pang, Chengbang Wang, Jiali Lin, Shaohua Chen, Jiangchun Wu, Junqi Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
ovarian cancer
single-cell RNA sequencing
exosome
biomarker
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1630794/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1630794/full

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