Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques

Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques

Mosquito-borne flaviviruses, including dengue (DENV) and Zika (ZIKV) viruses, have caused widespread epidemics in areas with high HIV prevalence, partly due to the expanded geographic range of arthropod vectors. Despite the occurrence of large flavivirus outbreaks in areas with high HIV prevalence,...

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Bibliographic Details
Main Authors: Jennifer Tisoncik-Go, Thomas B. Lewis, Leanne S. Whitmore, Kathleen Voss, Skyler Niemeyer, Jin Dai, Paul Kim, Kai Hubbell, Naoto Iwayama, Chul Ahrens, Solomon Wangari, Robert Murnane, Paul T. Edlefsen, Kathryn A. Guerriero, Michael Gale, Deborah H. Fuller, Megan A. O’Connor
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
Zika virus
co-infection
simian immunodeficiency virus (SIV)
nonhuman primate
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535807/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535807/full

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