Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions in the membrane. Here, we elucidate the intricate role of cardiolipin (CDL), a regulatory lipid, as a stabilizer of membrane proteins and their comple...

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Bibliographic Details
Main Authors: Mia L Abramsson, Robin A Corey, Jan L Skerle, Louise J Persson, Olivia Anden, Abraham O Oluwole, Rebecca J Howard, Erik Lindahl, Carol V Robinson, Kvido Strisovsky, Erik G Marklund, David Drew, Phillip J Stansfeld, Michael Landreh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
membrane protein
mass spectrometry
lipid binding
Online Access:https://elifesciences.org/articles/104237
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https://elifesciences.org/articles/104237

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