Inhibitory effect of Fisetin against the aggregation process of SOD1 E100K mutant: computer-based drug design as a potential therapeutic for ALS disease

Inhibitory effect of Fisetin against the aggregation process of SOD1 E100K mutant: computer-based drug design as a potential therapeutic for ALS disease

Protein misfolding and aggregation in superoxide dismutase 1 (SOD1) are linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). SOD1 mutations have a significant role in the pathophysiology and fast behavior of protopathic proteins in ALS illness. The E100K mutation may be usefu...

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Bibliographic Details
Main Authors: Fatemeh Sadat Seyedi Asl, Nasrin Malverdi, Fatemeh Sadat Ataei Kachouei, Fatemeh Zarei, Shamim Ghiabi, Payam Baziyar, Mohsen Nabi-Afjadi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Chemistry
Subjects:
ALS
E100K mutant
SOD1 aggregation
natural polyphenols
MD simulation
ADMET analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1569777/full
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https://www.frontiersin.org/articles/10.3389/fchem.2025.1569777/full

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