LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer

LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer

The tumor suppressor fragile histidine triad (FHIT) is frequently lost in non-small cell lung cancer (NSCLC). We previously showed that a down-regulation of FHIT causes an up-regulation of the activity of HER2 associated to an epithelial-mesenchymal transition (EMT) and that lung tumor cells harbori...

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Main Authors: Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:European Journal of Cell Biology
Subjects:
NSCLC
FHIT
HER2
LRP1
EMT
Online Access:http://www.sciencedirect.com/science/article/pii/S017193352400092X
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