Extraction of a stromal metastatic gene signature in breast cancer via spatial profiling

Extraction of a stromal metastatic gene signature in breast cancer via spatial profiling

Abstract Background The identification of molecular features characterizing metastatic disease is a critical area of oncology research, as metastatic foci often exhibit distinct biological behaviors compared to primary tumors. While the focus has largely been on the neoplastic cells themselves, the...

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Main Authors: Giorgio Bertolazzi, Valeria Cancila, Davide Vacca, Beatrice Belmonte, Daniele Lecis, Parsa Sirati Moghaddam, Arianna Di Napoli, Mario Paolo Colombo, Giancarlo Pruneri, Giannino Del Sal, Giorgio Scita, Matteo Fassan, Andrea Vecchione, Silvio Bicciato, Claudio Tripodo
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Spatial transcriptomics
Metastatic disease
Stromal microenvironment
Prognostic biomarker
Online Access:https://doi.org/10.1186/s13046-025-03353-3
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https://doi.org/10.1186/s13046-025-03353-3

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