Comprehensive immunophenotyping reveals distinct tumor microenvironment alterations in anti-PD-1 sensitive and resistant syngeneic mouse model

Comprehensive immunophenotyping reveals distinct tumor microenvironment alterations in anti-PD-1 sensitive and resistant syngeneic mouse model

Abstract The advent of immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway has revolutionized cancer treatment, resulting in improved clinical outcomes. However, resistance remains a critical challenge. This study aimed to comparatively elucidate immunophenotypic changes in syngeneic mouse...

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Bibliographic Details
Main Authors: Hiroyuki Inoue, Takayuki Hamasaki, Kazuhiko Inoue, Akira Nakao, Noriyuki Ebi, Hirofumi Minomo, Ichiro Nagata, Masaki Fujita, Naoto Horai
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Syngeneic mouse models
Anti-PD-1 antibody
Tumor immunophenotyping
Cytolytic activation marker
Online Access:https://doi.org/10.1038/s41598-025-91979-w
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https://doi.org/10.1038/s41598-025-91979-w

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