Multi-omics analysis of lactate metabolism gene regulation in Clonorchis sinensis-associated hepatocellular carcinoma

Multi-omics analysis of lactate metabolism gene regulation in Clonorchis sinensis-associated hepatocellular carcinoma

Abstract Background Although recent research has highlighted lactylation, a post-translational modification driven by elevated lactate levels, as a critical regulator of key cellular pathways in hepatocellular carcinoma (HCC), its contribution to the poor prognosis of Clonorchis sinensis (Cs)-infect...

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Main Authors: Qiumei Lin, Junxian Chen, Lingling Zhou, Min Fang, Caibiao Wei, Taijun Huang, Yulong Xu, Jie Gao, Fengfei Liu, Zeli Tang, Jian-Kang Zhu, Weilong Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Parasites & Vectors
Subjects:
Clonorchis sinensis
Hepatocellular carcinoma
Lactate metabolism
Multi-omics
Online Access:https://doi.org/10.1186/s13071-025-06947-0
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https://doi.org/10.1186/s13071-025-06947-0

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