Alternative Splicing Programs in Prostate Cancer
Prostate cancer (PCa) remains one of the most frequent causes of death for cancer in the male population. Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. The genetic and phenotypic heterogeneity of this type of cancer rend...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/458727 |
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| _version_ | 1832556573337059328 |
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| author | Claudio Sette |
| author_facet | Claudio Sette |
| author_sort | Claudio Sette |
| collection | DOAJ |
| description | Prostate cancer (PCa) remains one of the most frequent causes of death for cancer in the male population. Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. The genetic and phenotypic heterogeneity of this type of cancer renders its diagnosis and cure particularly challenging. Mounting evidence indicates that alternative splicing, the process that allows production of multiple mRNA variants from each gene, contributes to the heterogeneity of the disease. Key genes for the biology of normal and neoplastic prostate cells, such as those encoding for the androgen receptor and cyclin D1, are alternatively spliced to yield protein isoforms with different or even opposing functions. This review illustrates some examples of genes whose alternative splicing regulation is relevant to PCa biology and discusses the possibility to exploit alternative splicing regulation as a novel tool for prognosis, diagnosis, and therapeutic approaches to PCa. |
| format | Article |
| id | doaj-art-d56eac0eb4ae4a219ed5cac0e44ae9d5 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-d56eac0eb4ae4a219ed5cac0e44ae9d52025-02-03T05:44:58ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/458727458727Alternative Splicing Programs in Prostate CancerClaudio Sette0Department of Biomedicine and Prevention, University of Rome “Tor Vergata,” 00133 Rome, ItalyProstate cancer (PCa) remains one of the most frequent causes of death for cancer in the male population. Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. The genetic and phenotypic heterogeneity of this type of cancer renders its diagnosis and cure particularly challenging. Mounting evidence indicates that alternative splicing, the process that allows production of multiple mRNA variants from each gene, contributes to the heterogeneity of the disease. Key genes for the biology of normal and neoplastic prostate cells, such as those encoding for the androgen receptor and cyclin D1, are alternatively spliced to yield protein isoforms with different or even opposing functions. This review illustrates some examples of genes whose alternative splicing regulation is relevant to PCa biology and discusses the possibility to exploit alternative splicing regulation as a novel tool for prognosis, diagnosis, and therapeutic approaches to PCa.http://dx.doi.org/10.1155/2013/458727 |
| spellingShingle | Claudio Sette Alternative Splicing Programs in Prostate Cancer International Journal of Cell Biology |
| title | Alternative Splicing Programs in Prostate Cancer |
| title_full | Alternative Splicing Programs in Prostate Cancer |
| title_fullStr | Alternative Splicing Programs in Prostate Cancer |
| title_full_unstemmed | Alternative Splicing Programs in Prostate Cancer |
| title_short | Alternative Splicing Programs in Prostate Cancer |
| title_sort | alternative splicing programs in prostate cancer |
| url | http://dx.doi.org/10.1155/2013/458727 |
| work_keys_str_mv | AT claudiosette alternativesplicingprogramsinprostatecancer |