Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes

Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes

Abstract Background Natural HbA1c levels in GCK Maturity-onset diabetes of the young (GCK-MODY) patients often sit above the diagnostic threshold for type 2 diabetes (T2D). Treatments to lower HbA1c levels show reduced effectiveness in these individuals, yet in case studies to date, GCK-MODY patient...

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Main Authors: Kelly M. Schiabor Barrett, Natalie Telis, Lisa M. McEwen, Evanette K. Burrows, Basil Khuder, Daniel P. Judge, Pamala A. Pawloski, Joseph J. Grzymski, Nicole L. Washington, Alexandre Bolze, Elizabeth T. Cirulli
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-024-00663-z
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https://doi.org/10.1038/s43856-024-00663-z

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