Amoxicillin-induced bacterial gut dysbiosis decreases IL-1β and IL-6 expression but exacerbate lung inflammatory response against Mycobacterium bovis-Bacille Calmette-Guérin (BCG).

Amoxicillin-induced bacterial gut dysbiosis decreases IL-1β and IL-6 expression but exacerbate lung inflammatory response against Mycobacterium bovis-Bacille Calmette-Guérin (BCG).

Tuberculosis is one of the leading causes of global mortality, and the standard, prolonged, and intensive treatment can affect intestinal homeostasis. This study investigated amoxicillin-induced bacterial gut dysbiosis and its impact on the immune response of C57BL/6 mice to pulmonary infection by M...

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Main Authors: Tatimara M Miyauchi-Tavares, Evandro Neves Silva, Joyce Alves Dos Santos, Priscila V Sousa, Marcos F Teodoro Braga, Caroline M Carminatti, Victoria B Lanza, Bruna C Fagundes, Rômulo Dias Novaes, Leonardo Augusto de Almeida, Patrícia Paiva Corsetti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0319382
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https://doi.org/10.1371/journal.pone.0319382

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