Transcriptomic profiling of severe and critical COVID-19 patients reveals alterations in expression, splicing and polyadenylation

Transcriptomic profiling of severe and critical COVID-19 patients reveals alterations in expression, splicing and polyadenylation

Abstract Coronavirus disease 2019 (COVID-19) is a multi-systemic illness that became a pandemic in March 2020. Although environmental factors and comorbidities can influence disease progression, there is a lack of prognostic markers to predict the severity of COVID-19 illness. Identifying these mark...

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Main Authors: Marjorie Labrecque, Elsa Brunet-Ratnasingham, Laura K. Hamilton, Daniel Auld, Alexandre Montpetit, Brent Richards, Madeleine Durand, Simon Rousseau, Andrés Finzi, Daniel E. Kaufmann, Martine Tetreault
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
COVID-19
Transcriptomics
Differentially expressed genes
Alternative splicing
Alternative polyadenylation
Pathway enrichment
Online Access:https://doi.org/10.1038/s41598-025-95905-y
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https://doi.org/10.1038/s41598-025-95905-y

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