Targeted screening and profiling of massive components of colistimethate sodium by two-dimensional-liquid chromatography-mass spectrometry based on self-constructed compound database

Targeted screening and profiling of massive components of colistimethate sodium by two-dimensional-liquid chromatography-mass spectrometry based on self-constructed compound database

In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics. Similarities and variations of components present significant analytical challenges. A two-dimensional (2D) liquid chromatography-mass spectrometr (LC-MS) method was established for scr...

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Bibliographic Details
Main Authors: Xuan Li, Minwen Huang, Yue-Mei Zhao, Wenxin Liu, Nan Hu, Jie Zhou, Zi-Yi Wang, Sheng Tang, Jian-Bin Pan, Hian Kee Lee, Yao-zuo Yuan, Taijun Hang, Hai-Wei Shi, Hongyuan Chen
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Colistimethate sodium
2D-LC-MS
Profiling
Targeted screening
Component deduction
Database
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177924001692
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