Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response

Summary: Identifying host genetic factors modulating immune checkpoint inhibitor (ICI) efficacy is experimentally challenging. Our approach, utilizing the Collaborative Cross mouse genetic resource, fixes the tumor genomic configuration while varying host genetics. We find that response to anti-PD-1...

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Main Authors: Daniel A. Skelly, John P. Graham, Mingshan Cheng, Mayuko Furuta, Andrew Walter, Thomas A. Stoklasek, Hongyuan Yang, Timothy M. Stearns, Olivier Poirion, Ji-Gang Zhang, Jessica D.S. Grassmann, Diane Luo, William F. Flynn, Elise T. Courtois, Chih-Hao Chang, David V. Serreze, Francesca Menghi, Laura G. Reinholdt, Edison T. Liu
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004693
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