Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research

Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research

Abstract Osteoarthritis (OA) is a highly prevalent and disabling condition lacking curative treatments, with only symptomatic relief available. Recognizing OA as a heterogenous disorder with diverse aetiologies and molecular foundations underscores the need to classify patients by both phenotypes an...

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Bibliographic Details
Main Authors: Eva Reihs, Anita Fischer, Iris Gerner, Reinhard Windhager, Stefan Toegel, Frank Zaucke, Mario Rothbauer, Florien Jenner
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
In vivo models
Stratification
Pathophenotypes
Matchmaking
Online Access:https://doi.org/10.1186/s13075-025-03561-4
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https://doi.org/10.1186/s13075-025-03561-4

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