Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs, particularly in the major human mould pathogen Aspergillus fumigatus, is emerging and reaching levels that have prompted some to suggest that...

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Main Authors: Fabio Gsaller, Peter Hortschansky, Takanori Furukawa, Paul D Carr, Bharat Rash, Javier Capilla, Christoph Müller, Franz Bracher, Paul Bowyer, Hubertus Haas, Axel A Brakhage, Michael J Bromley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005775&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005775&type=printable

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