Endothelial Cpt1a Inhibits Neonatal Hyperoxia‐Induced Pulmonary Vascular Remodeling by Repressing Endothelial‐Mesenchymal Transition

Endothelial Cpt1a Inhibits Neonatal Hyperoxia‐Induced Pulmonary Vascular Remodeling by Repressing Endothelial‐Mesenchymal Transition

Abstract Pulmonary hypertension (PH) increases the mortality of preterm infants with bronchopulmonary dysplasia (BPD). There are no curative therapies for this disease. Lung endothelial carnitine palmitoyltransferase 1a (Cpt1a), the rate‐limiting enzyme of the carnitine shuttle system, is reduced in...

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Main Authors: Xiaoyun Li, Katy Hegarty, Fanjie Lin, Jason L. Chang, Amro Abdalla, Karthik Dhanabalan, Sergey O. Solomevich, Wenliang Song, Karim Roder, Chenrui Yao, Wenju Lu, Peter Carmeliet, Gaurav Choudhary, Phyllis A. Dennery, Hongwei Yao
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
bronchopulmonary dysplasia
metabolic reprograming
nanoparticle‐mediated gene delivery
pulmonary hypertension
single‐cell RNA transcriptomics
Online Access:https://doi.org/10.1002/advs.202415824
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https://doi.org/10.1002/advs.202415824

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