Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-κB pathway

Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-κB pathway

Cognitive impairments following post-stroke significantly hinder neurological recovery and exacerbate patient morbidity, underscoring urgent need for effective therapeutic strategies. Vortioxetine (VTX), a prominent Selective Serotonin Reuptake Inhibitor (SSRI), boasts notable antidepressant, cognit...

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Bibliographic Details
Main Authors: Ziqiang Dong, Zhihui Dong, Lili Xu, Jinfeng Zhang, Lin Li, Rongjuan Wang, Xiaoyan Huang, Zhengqiang Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
vortioxetine
ischemic stroke
cognitive dysfunction
neuroinflammation
TLR-2/NF-κB pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1555079/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1555079/full

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