Recent Advances in the Development of Immunoproteasome Inhibitors as Anti-Cancer Agents: The Past 5 Years

Recent Advances in the Development of Immunoproteasome Inhibitors as Anti-Cancer Agents: The Past 5 Years

The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed in response to cellular stress or inflammatory stimuli. The primary role of the iCP is to hydrolyze proteins into peptides that can be loaded into the MHC-I complex. Beyond its primary role in the adaptive immune respon...

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Bibliographic Details
Main Authors: Francesca Mancuso, Carla Di Chio, Francesca Di Matteo, Gerardina Smaldone, Nunzio Iraci, Salvatore Vincenzo Giofrè
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
immunoproteasome
cancer
covalent inhibitors
non-covalent inhibitors
peptide backbone
non-peptide inhibitors
Online Access:https://www.mdpi.com/1420-3049/30/3/755
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