Single cell analysis reveals that SPP1+ macrophages enhance tumor progression by triggering fibroblast extracellular vesicles

Single cell analysis reveals that SPP1+ macrophages enhance tumor progression by triggering fibroblast extracellular vesicles

Abstracts: Patients with liver metastatic colorectal cancer (mCRC) have a poor prognosis and are the leading cause of death in colorectal cancer (CRC) patients, but the mechanisms associated with CRC metastasis have not been fully elucidated. In this study, we obtained data from the Gene Expression...

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Main Authors: Haocheng Wang, Bowen Qiu, Xinyu Li, Yao Ying, Yue Wang, Hungchen Chen, Fanan Zeng, Junyao Shi, Junpeng Huang, Ziying Wu, Zequn Chen, Xiao Che, Qingzhong Li, Yingming Fan, Bingyao Li, Qun Wang, Chengyu Huang, Yixuan Chen, Ting Li, Ke Mo, Qian Wang, Chunhui Cui
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Translational Oncology
Subjects:
mCRC
Single-cell RNA sequencing
Intercellular communication
Liver
TME
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325000786
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